Schistosity; Crotane type; Plant extract; Natural products; Natural products library
Biological Activities
↓ Click to view data in tabs below
Scutebarbatine B
$1,499.00
CAS Number: 905929-95-5
Synonyms:Melelabine B
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 5mg | $1,499.00 | In stock |
Description
Additional information
| Size |
5mg |
|---|---|
| Purity |
95% |
| M.F. |
C33H35NO7 |
| Appearance |
Powder |
| H NMR |
Available |
Biological Activity
Reported Biological Activities
Click each activity to expand detailed pharmacology data.
✨
Anticancer
in vitro
IC50 35.11-42.73 uM (K562, HL60)
−
IC50
IC50 35.11-42.73 uM (K562, HL60)
Potency
Medium (3/5)
K562 IC50
35.11-42.73 uM
HL60 IC50
35.11-42.73 uM
HONE-1/KB/HT29
3.5-8.1 mM
Mechanism
apoptosis + Stat3/NF-kB inhibition
Mechanism of Action
Neo-clerodane diterpenoid alkaloid from Scutellaria barbata; cytotoxic against multiple human cancer cell lines: K562 leukemia and HL60 promyelocytic leukemia (IC50 35.11-42.73 uM); HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma (IC50 3.5-8.1 mM); induces apoptosis via cell cycle arrest, inhibits Stat3 and NF-kB signaling, regulates Bcl-2/Bax ratio; related scutebarbatine A induces caspases-3/9 cleavage and cytochrome c efflux.
References
1. Scutebarbatine B cytotoxic against K562 and HL60. PMID: Cytotoxic neoclerodane diterpenoids from Scutellaria barbata.
🔥
Anti-inflammatory
in vitro
+
⚠️ These biological activity data are for research reference only. Products are reagents for research use only and are not intended for human use.
Natural Sources
Natural Sources
This compound can be found in the following natural sources. Each source is categorized by type.
🌿
Plant
Scutellaria barbata
Barbed skullcap / Ban Zhi Lian. Scutebarbatine B isolated from whole plants of this Lamiaceae species; traditional Chinese medicine for heat-clearing, detoxification, tumors, hepatitis, inflammation; extracted by 70-95% ethanol reflux, D101 macroporous resin enrichment, silica/ODS column, preparative HPLC; neo-clerodane diterpenoid alkaloids first discovered in this genus.
Source Categories:
🌿 Plant
🦠 Microbe
🐛 Animal
🌊 Marine
Source information is for research reference only. Products are reagents for research use only and are not intended for human use.
Reviews (0)
ANSWERS TO EVERYTHING ELSE
How can I obtain product Data Sheet, Certficate of Analysis, spectrums like 1H NMR or HPLC etc?
You can directly contact our customer service or send an email to info@acubiochem.com. We will provide feedback within 24 hours. Generally, we send a copy of the relevant technical documents to your email when we send the quotation and before shipment. Our technical documents typically include the quality inspection report, safety data sheet, and all relevant detection spectra, such as NMR and HPLC. If customers require special testing, they can specify this when placing the order.
What should I do if I have special quality requirements for the product?
Our company offers custom synthesis services. The products listed on our website are only a portion of what we provide. We can customize our services based on specific quality requirements from customers, such as purity, impurity content, moisture content, and any other quality indicators. Simply contact our customer service or send an email to info@acubiochem.com to discuss your needs.
What should I do if I want packaging in a different size？
Our company offers custom packaging services. If the packaging listed on our website does not meet your requirements, whether you need smaller or larger packaging, you can directly contact our customer service or send an email to info@acubiochem.com. Our customer service team will get in touch with you within 24 hours to customize the packaging size according to your needs.
What are the shipping conditions of your product?
Most of our products are stable at room temperature, so they are typically shipped at room temperature. For special products, we use ice packs or dry ice for transportation based on the product's stability. Additionally, if customers need to record the temperature during transportation, they can contact us directly to request this. Our company provides data loggers that can continuously record the temperature inside the packaging.
How can I check the status of my order after placing it?
After placing an order, our company provides one-on-one dedicated service for each order. The assigned shipping representative will offer services such as order confirmation, technical document updates, delivery updates, and tracking number updates. If you want to confirm the status of your order, you can directly contact your assigned shipping representative or send an email to info@acubiochem.com, and you will receive feedback within 24 hours.
What should I do if I want to learn about the technical information of a product, such as stability, solubility, and other related properties?
Our company offers free technical consulting services to all customers. If you have any questions regarding the products you inquire about, you can directly contact our customer service representatives or send an email to info@acubiochem.com. We will respond to you within 24 hours.
I have other questions I would like to know about?
Please directly contact our customer service representatives or send an email to info@acubiochem.com. We will respond to you within 24 hours. Your satisfaction is our unwavering pursuit.
Reviews
There are no reviews yet.