Anti-tumor; Anticancer; Danshen; Red root grass; Diterpenoid quinone; Herbology Reference; Herbology Standard; Plant extract; Natural products; Natural products library
Biological Activities
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8,9-Dihydro-4,8-dimethylphenanthro(3,2-b)furan-7,11-dione
$1,499.00
CAS Number: 20958-18-3
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 5mg | $1,499.00 | In stock |
Description
Additional information
| Size |
5mg |
|---|---|
| Purity |
95% |
| M.F. |
C18H14O3 |
| Appearance |
Red powder |
| H NMR |
Available |
Biological Activity
Reported Biological Activities
Click each activity to expand detailed pharmacology data.
✨
Anticancer
in vitro
ED50 2.5 uM (thyroid cancer); IC50 1-20 uM (various)
−
IC50
ED50 2.5 uM (thyroid cancer); IC50 1-20 uM (various)
Potency
High (4/5)
Thyroid cancer ED50
2.5 uM (beta-catenin down)
HCC apoptosis
30-40% at 5 uM
Endometrial
10 uM apoptosis+ferroptosis
Glioblastoma
STAT3 inhibitor
Esophageal
STAT3 + mitochondrial pathway
Mechanism of Action
Norditerpenoid quinone from Salvia miltiorrhiza; multi-pathway antitumor agent: inhibits STAT3 signaling (esophageal cancer, glioblastoma), downregulates beta-catenin (papillary thyroid cancer ED50 2.5 uM), induces DNA damage and EGFR pathway inhibition (hepatocellular carcinoma, 5 uM induces 30-40% apoptosis), triggers ferroptosis and apoptosis via GPX4 suppression (endometrial cancer, 10 uM), induces ER stress (prostate DU145), activates p38-mediated apoptosis (head and neck cancer); in vivo reduces tumor growth in xenograft models without obvious hepatotoxicity.
References
1. DHTS antitumor via beta-catenin downregulation in thyroid cancer. PMID: STAT3-mediated antitumor in esophageal SCC. PMC8371523
🔥
Anti-inflammatory
in vitro
+
🦠
Antibacterial
in vitro
+
⚠️ These biological activity data are for research reference only. Products are reagents for research use only and are not intended for human use.
Natural Sources
Natural Sources
This compound can be found in the following natural sources. Each source is categorized by type.
🌿
Plant
Salvia miltiorrhiza
Danshen / Chinese sage. Dihydrotanshinone I is a major lipid-soluble tanshinone in roots; extracted by 95% ethanol reflux, water precipitation, ethyl acetate/petroleum ether extraction, silica gel column chromatography; often co-occurs with tanshinone IIA, tanshinone I, cryptotanshinone; used in cardiovascular disease and ischemic stroke.
Source Categories:
🌿 Plant
🦠 Microbe
🐛 Animal
🌊 Marine
Source information is for research reference only. Products are reagents for research use only and are not intended for human use.
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