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Biological Activities
✨ Antidepressant in vitro 🦠 Antibacterial in vitro ☠️ Cytotoxic in vitro
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Home Natural Compounds 2-Geranyl-4-isobutyrylphloroglucinol
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2-Geranyl-4-isobutyrylphloroglucinol

$1,207.50

CAS Number: 72008-03-8
Synonym: 3-Geranyl-1-(2′-methylpropanoyl)phloroglucinol; 1-[3-geranyl-2,4,6-trihydroxyphenyl]-2-methylpropan-1-one; 1-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4,6-trihydroxyphenyl]-2-methylpropan-1-one; 1-[3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2,4,6-trihydroxy-phenyl]-2-methyl-propan-1-one

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PuritySizePriceStockQuantity
95%5mg$1,207.50In stock
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    SKU: ACU040006 Category: Natural Compounds
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    • Description
    • Additional information
    • Biological Activity
    • Natural Sources
    • Reviews (0)
    • ANSWERS TO EVERYTHING ELSE
    Description

    2-Geranyl-4-isobutyrylphloroglucinol is a natural product compound with a distinctive molecular architecture characterized by a unique arrangement of functional groups and ring systems that confer specific chemical reactivity and biological properties. This natural product occurs in diverse biological sources including plants, fungi, bacteria, and marine organisms, where it is biosynthesized through specialized enzymatic pathways as a secondary metabolite serving ecological functions such as defense, signaling, or pigmentation The compound shows promising bioactivity profiles that are under investigation, potentially encompassing antimicrobial, anti-inflammatory, cytotoxic, or enzyme modulatory effects relevant to various research applications in pharmaceutical and chemical biology As a natural product, this compound exhibits a range of biological activities including antimicrobial, anti-inflammatory, antioxidant, antitumor, or enzyme inhibitory properties depending on its specific structural features and functional group arrangement The biological effects are mediated through specific molecular interactions that are being elucidated through structure-activity relationship studies, target identification experiments, and mechanistic investigations using biochemical and cellular assay systems In pharmaceutical and chemical research, this natural product serves as a valuable chemical entity for drug discovery, lead optimization, biological probe development, and understanding of structure-activity relationships that guide rational drug design strategies

    Additional information
    Size

    5mg

    Purity

    95%

    M.F.

    C20H28O4

    Appearance

    Yellow powder

    M.W.

    332.44

    Smiles

    CC(C)C(=O)C1=C(C=C(C(=C1O)C/C=C(\C)/CCC=C(C)C)O)O

    Storage

    Store at room temperature for short-term use; store at -20°C for long-term storage.

    Biological Activity

    Reported Biological Activities

    Click each activity to expand detailed pharmacology data.

    ✨ Antidepressant in vitro
    −
    Potency
    Low (2/5)
    Related compound
    hyperforin (TRPC6 activator)
    Predicted activity
    antidepressant
    Mechanism of Action
    Acylphloroglucinol (PPAP) derivative; structurally related to hyperforin from Hypericum perforatum (St. Johns wort); hyperforin inhibits neurotransmitter reuptake (5-HT, dopamine, norepinephrine) via TRPC6 channel activation and intracellular sodium/calcium homeostasis modulation; this compound predicted to have similar antidepressant potential but lacks systematic pharmacological evidence.
    References
    1. Phloroglucinols: review of chemistry, biology, and applications. Hyperforin TRPC6 mechanism.
    🦠 Antibacterial in vitro
    +
    Potency
    Low (2/5)
    Compound class
    acylphloroglucinol
    Related MRSA compounds
    lupulone, rhodomyrtone, hyperforin
    Isobutyryl analogs
    strongest antibacterial
    Mechanism of Action
    Prenylated acylphloroglucinol class; phloroglucinol derivatives are among most promising antibacterial compounds against MRSA (e.g., lupulone, rhodomyrtone, hyperforin); diacyl phloroglucinol analogs show high antibacterial activity against Flavobacterium columnare; diisovaleryl and diisobutyryl analogs strongest; this compound has isobutyryl group suggesting potential antibacterial activity.
    References
    1. Structure-dependent activity of plant natural products against MRSA. PMC10463185 PMID: Antibacterial activity of acylglucinol derivatives. SCIRP
    ☠️ Cytotoxic in vitro IC50 22.5 ug/mL (Vero cells)
    +
    IC50
    IC50 22.5 ug/mL (Vero cells)
    Potency
    Low (2/5)
    Vero cell IC50
    22.5 ug/mL (48 hrs)
    Assay
    neutral red dye
    Mechanism of Action
    Acylphloroglucinol derivative; moderate cytotoxicity against African green monkey Vero cells (IC50 22.5 ug/mL, 48 hrs, neutral red dye assay); lipophilic geranyl side chain contributes to membrane interaction; PPAP class compounds generally show cytotoxic and antitumor potential.
    References
    1. Cytotoxicity against Vero cells assessed by neutral red method. PMID: 27584935
    ⚠️ These biological activity data are for research reference only. Products are reagents for research use only and are not intended for human use.
    Natural Sources

    Natural Sources

    This compound can be found in the following natural sources. Each source is categorized by type.

    🌿
    Plant
    Hypericum species
    St. Johns wort genus. Acylphloroglucinols are characteristic secondary metabolites of Hypericum genus; Hypericum perforatum contains hyperforin and adhyperforin; related 4-geranyloxy-1-(2-methylpropanoyl)phloroglucinol isolated from Hypericum densiflorum; this compound likely present in Hypericum flowers and leaves; extracted with hexane-acetone or dichloromethane-methanol.
    Source Categories: 🌿 Plant 🦠 Microbe 🐛 Animal 🌊 Marine
    Source information is for research reference only. Products are reagents for research use only and are not intended for human use.
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