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Biological Activities
✨ Anticancer in vitro 🦠 Antibacterial in vitro ✨ Insecticidal in vitro
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Home Natural Compounds Kamebanin
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8-Phenyloctanoic acid
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Kamebanin

$1,250.00

CAS Number: 39388-57-3
Synonym: (1,7,14R)-1,7,14-Trihydroxykaur-16-en-15-one; (1R,2R,4R,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-5,5,9-trimethyl-14-methylene-tetracyclo[11.2.1.01,10.04,9]hexadecan-15-one

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PuritySizePriceStockQuantity
98%5mg$1,250.00In stock
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    SKU: ACU040013 Category: Natural Compounds
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    • Description
    • Additional information
    • Biological Activity
    • Natural Sources
    • Reviews (0)
    • ANSWERS TO EVERYTHING ELSE
    Description

    Kamebanin is a natural product compound with a distinctive molecular architecture characterized by a unique arrangement of functional groups and ring systems that confer specific chemical reactivity and biological properties. Natural products of this diverse class are found across various organisms in terrestrial and marine environments, with many serving as defense compounds, signaling molecules, or secondary metabolites with unique ecological functions that have evolved through natural selection The compound shows promising bioactivity profiles that are under investigation, potentially encompassing antimicrobial, anti-inflammatory, cytotoxic, or enzyme modulatory effects relevant to various research applications in pharmaceutical and chemical biology As a natural product, this compound exhibits a range of biological activities including antimicrobial, anti-inflammatory, antioxidant, antitumor, or enzyme inhibitory properties depending on its specific structural features and functional group arrangement This natural product exerts its effects through interaction with specific biological targets, modulation of cellular signaling pathways, alteration of enzyme activities, or influence on membrane functions, depending on its chemical properties and functional group complementarity to target binding sites Current applications include its use as a research chemical in pharmacological screening, as a starting point for synthetic modification and drug development, and as a molecular tool for studying biological processes and validating new therapeutic targets

    Additional information
    Size

    5mg

    Purity

    98%

    M.F.

    C20H30O4

    Appearance

    Powder

    M.W.

    334.46

    Smiles

    C[C@]12[C@@H]3CC[C@@H]4[C@H]([C@@]3([C@@H](C[C@@H]1C(CC[C@@H]2O)(C)C)O)C(=O)C4=C)O

    Storage

    Store at room temperature for short-term use; store at -20°C for long-term storage.

    Biological Activity

    Reported Biological Activities

    Click each activity to expand detailed pharmacology data.

    ✨ Anticancer in vitro IC50 3.3 uM (HL-60); IC50 8.4 uM (MCF7)
    −
    IC50
    IC50 3.3 uM (HL-60); IC50 8.4 uM (MCF7)
    Potency
    High (4/5)
    HL-60 IC50
    3.3 uM
    MCF7 IC50
    8.4 uM (48 hrs)
    KB cells
    significant cytotoxic
    In vivo
    Walker carcinosarcoma inhibition
    1-O-acyl derivs
    increased cytotoxicity (HL60, HCT116)
    Mechanism of Action
    ent-Kaurane diterpenoid from Isodon kameba; original isolation paper reports in vitro cytotoxicity, in vivo tumor inhibitory, and antibacterial activities; efficient cytotoxicity against HeLa and HL-60 human cancer cells; HL-60 IC50 3.3 uM, MCF7 IC50 8.4 uM (48 hrs WST-8); significant in vitro cytotoxicity against KB cells; in vivo tumor inhibitory activity against Walker intramuscular carcinosarcoma in rats; 1-O-acyl derivatives (C3-C5 chain) show increased cytotoxicity against HL60 and HCT116; ent-kaurane class generally induces apoptosis via NF-kB inhibition, caspases activation.
    References
    1. THE STRUCTURE OF KAMEBANIN, A NEW ANTITUMOR ENT-KAURENOID FROM ISODON KAMEBA. Chem Lett 1977. PMID: Kamebanin efficient cytotoxic against HeLa and HL-60.
    🦠 Antibacterial in vitro
    +
    Potency
    Low (2/5)
    Reported activity
    antibacterial (original paper)
    Mechanism of Action
    ent-Kaurane diterpenoid; original isolation paper reports antibacterial activity; ent-kaurane class compounds from Isodon genus generally have antimicrobial properties; specific bacterial strains and MIC data for kamebanin limited.
    References
    1. Kamebanin: antibacterial activity reported in isolation paper. Chem Lett 1977.
    ✨ Insecticidal in vitro
    +
    Potency
    Low (2/5)
    Target insects
    Lepidoptera larvae
    Activity type
    specific insecticidal
    Mechanism of Action
    ent-Kaurane diterpenoid; reported specific insecticidal activity against Lepidoptera larvae; ent-kaurane diterpenoids from Isodon genus often have insecticidal and antifeedant properties; kamebanin structure with multiple oxygenated groups may contribute to insecticidal effects.
    References
    1. Natural diterpenoid kamebanin: insecticidal activity against Lepidoptera larvae. IUCr
    ⚠️ These biological activity data are for research reference only. Products are reagents for research use only and are not intended for human use.
    Natural Sources

    Natural Sources

    This compound can be found in the following natural sources. Each source is categorized by type.

    🌿
    Plant
    Isodon kameba (Rabdosia kameba)
    Kameba isodon. Kamebanin first isolated from dry leaves of Isodon kameba (formerly Rabdosia kameba) Okuyama; also isolated from Rabdosia umbrosa; ent-kaurane diterpenoids are characteristic of Isodon/Rabdosia genus; extracted by ethanol/methanol, activated carbon decolorization, silica/ODS/Sephadex LH-20, preparative HPLC; structure first reported 1977.
    🌿
    Plant
    Rabdosia excisa
    Kamebanin isolated from Rabdosia excisa along with related ent-kaurane diterpenoids; used for synthesis of 1-O-acyl and 1-oxo-kamebanin analogues with enhanced cytotoxicity; Rabdosia genus rich in bioactive ent-kaurane diterpenoids.
    Source Categories: 🌿 Plant 🦠 Microbe 🐛 Animal 🌊 Marine
    Source information is for research reference only. Products are reagents for research use only and are not intended for human use.
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      Products are reagents for research use only and are not intended for human use. We do not sell to patients.

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