Neocarzinostatin (NCS, NSC 69856) is a protein‑chromophore complex that induces DNA double‑strand breaks by recognizing DNA bulges and inhibiting DNA polymerase‑I. It inhibits DNA synthesis and causes degradation. Neocarzinostatin is an enediyne antibiotic chromoprotein isolated from Streptomyces carzinostaticus. In research, it is used as a potent DNA‑damaging agent for studying repair pathways and as a tool for targeted cancer therapy via conjugation.
Neocarzinostatin
$1,880.00
CAS Number: 9014-02-2
Synonyms: NCS, NSC 69856
Mechanism of Action: DNA Cleaver / Alkylator (Dual)
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 90% | 100ug | $1,880.00 | In stock |
Description
Additional information
| Size |
100ug |
|---|---|
| Purity |
90% |
| M.F. |
Protein-chromophore complex |
| M.W. |
~12 kDa (protein) |
| Appearance |
White amorphous powder / Pale-yellow powder |
| Melting Point |
260°C (dec.) |
| Storage |
Store long-term at -20°C |
| Smiles |
CN[C@H]1C@@HOC@@HC- |
Biological activity
| Biological target: | DNA Damage; DNA; DNA (dual: break + crosslink) |
| In vitro activity: | Recognizes DNA bulges; induces double‑strand breaks; inhibits DNA polymerase‑I. |
| In vivo activity: | Causes DNA strand breaks in vivo; used as chemotherapeutic. |
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