Illudin S (NSC 20092) is a potent antitumor sesquiterpene that is metabolically activated to reactive intermediates that alkylate DNA, inhibiting DNA synthesis. It shows activity against multidrug‑resistant tumors in vivo. Illudin S is isolated from the mushroom Omphalotus illudens (Jack‑o’‑lantern mushroom). In research, it is used as a lead for semisynthetic derivatives (e.g., irofulven) and to study DNA alkylation and apoptosis.
Illudin S
$998.00
CAS Number: 1149-99-1
Synonyms: NSC 20092, Lampterol
Mechanism of Action: DNA Alkylator (Michael Acceptor)
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 1mg | $998.00 | In stock |
Description
Additional information
| Size |
1mg |
|---|---|
| Purity |
95% |
| M.F. |
C₁₅H₂₀O₃ |
| M.W. |
248.32 |
| Appearance |
Light yellow solid |
| Melting Point |
124-126°C |
| Storage |
Store long-term at -20°C |
| Smiles |
CC1=C2C@HO- |
Biological activity
| Biological target: | DNA Damage; DNA (alkylation); DNA (thiol alkylation) |
| In vitro activity: | Metabolically activated to reactive intermediates that bind DNA; inhibits DNA synthesis. |
| In vivo activity: | Active against MDR tumors in vivo. |
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