Sirolimus (Rapamycin, AY-22989) is a potent and specific mTOR inhibitor that binds to FKBP-12 to form a complex which inhibits mTORC1 activation. It inhibits mTOR activity in HEK293 cells with an IC₅₀ of approximately 0.1 nM and in mouse TSC1⁻/⁻ MEF cells with an IC₅₀ of 0.05 nM. Sirolimus is a 31‑membered triene macrolide antibiotic. It was first isolated from Streptomyces hygroscopicus obtained from a soil sample on Easter Island (Rapa Nui) and was initially identified as an antifungal agent. Sirolimus is widely used in biological research as an immunosuppressant to prevent organ transplant rejection, as an inducer of autophagy, and as a tool for chemically induced dimerization (CID) in studying protein‑protein interactions.
Sirolimus
Price range: $199.00 through $4,980.00
CAS Number: 53123-88-9
Synonyms: Rapamycin, AY-22989, Rapamune, RAPA, RPM, NSC 226080
Mechanism of Action: mTORC1 Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 1g | $199.00 | In stock | |
| 100% | 5g | $4,980.00 | In stock |
Description
Additional information
| Size |
1g, 5g |
|---|---|
| Purity |
98%, 100% |
| M.F. |
C₅₁H₇₉NO₁₃ |
| M.W. |
914.17 |
| Appearance |
White to off-white crystalline powder |
| Melting Point |
183-185°C |
| Storage |
Store long-term at -20°C |
| Smiles |
O=C([C@@]1(O)C@@HC)C(N3CCCC[C@H]3C(OC@@HC@@HC)=O)=O-6 |
| MDL No |
MFCD00867594-2 |
| Precautionary Statement Code |
P260, P403+P235, P501- |
| GHS Information |
Signal Word: Danger; H351: Suspected of causing cancer; H361: Suspected of damaging fertility or the unborn child; H372: Causes damage to organs through prolonged or repeated exposure- |
| Harmonized Tariff Codes |
3822.90.0000 (as certified standard)-; UN1993, Class 3, PG III-2 |
Biological activity
| Biological target: | #REF! |
| In vitro activity: | Binds FKBP12, inhibits mTORC1; IC₅₀ for IL-2-stimulated T-cell proliferation ~0.5–1 nM. Inhibits growth of multiple cancer cell lines (IC₅₀ 0.1–10 nM). |
| In vivo activity: | Prolongs allograft survival in mice, rats, and pigs; suppresses autoimmune disease models (e.g., SLE, collagen-induced arthritis). FDA‑approved immunosuppressant. |
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