Geldanamycin (NSC 122750, Antibiotic TAN 420) is a potent inhibitor of heat shock protein 90 (HSP90) that binds to the ATP‑binding pocket and inhibits its ATPase activity in a dose‑dependent manner. It causes G2 arrest in A2780 ovarian cancer cells and reduces mutated p53 levels. Geldanamycin is a benzoquinone ansamycin antibiotic first isolated from Streptomyces hygroscopicus var. geldanus. In research, it is used as a tool to study HSP90 chaperone function, protein folding, and as a lead compound for developing HSP90 inhibitors (e.g., 17‑AAG) in cancer research.
Geldanamycin
Price range: $399.00 through $699.00
CAS Number: 30562-34-6
Synonyms: NSC 122750, Antibiotic TAN 420
Mechanism of Action: HSP90 Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 500mg | $399.00 | In stock | |
| 95% | 1g | $699.00 | In stock |
Description
Additional information
| Size |
500mg, 1g |
|---|---|
| Purity |
98%, 95% |
| M.F. |
C₂₉H₄₀N₂O₉ |
| M.W. |
560.64 |
| Appearance |
Yellow powder |
| Melting Point |
255°C |
| Storage |
Store long-term at -20°C- |
| MDL No |
MFCD00274570- |
Biological activity
| Biological target: | Protein Homeostasis; HSP90; HSP90 (ATPase site) |
| In vitro activity: | Binds to HSP90 ATPase; inhibits ATPase activity dose‑dependently. Causes G2 arrest in A2780 cells. |
| In vivo activity: | Inhibits chick skeletal myogenesis; prevents IL‑13‑induced goblet cell metaplasia; decreases mutated p53 in vivo. |
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