Trichostatin A (TSA, NSC 145080) is a potent and selective inhibitor of class I and II HDACs with a Ki of 3.4 nM and IC₅₀ values: HDAC1 4.99 nM, HDAC3 5.21 nM, HDAC6 16.4 nM, HDAC10 24.3 nM, and HDAC4 27.6 nM. It inhibits proliferation of breast cancer cell lines with a mean IC₅₀ of 124 nM. Trichostatin A is a hydroxamic acid antibiotic first isolated from Streptomyces hygroscopicus. It is a standard tool in epigenetics research for inducing histone hyperacetylation, studying gene expression regulation, and as a potent anti‑cancer agent in vitro and in vivo.
Trichostatin A
$1,980.00
CAS Number: 58880-19-6
Synonyms: TSA, NSC 145080
Mechanism of Action: Pan-HDAC Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 97% | 100mg | $1,980.00 | In stock |
Description
Additional information
| Size |
100mg |
|---|---|
| Purity |
97% |
| M.F. |
C₁₇H₂₂N₂O₃ |
| M.W. |
302.37 |
| Appearance |
White to orange to green powder to crystal |
| Melting Point |
144°C |
| Storage |
Frozen (<0°C); Protect from heat- |
| Smiles |
CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C- |
| MDL No |
MFCD03848392- |
| Precautionary Statement Code |
P270, P330, P501, P280, P321, P261, P272, P271, P319, P405, P301+P317, P302+P352, P362+P364, P332+P317, P333+P317, P264+P265, P305+P351+P338, P337+P317, P304+P340, P403+P233- |
Biological activity
| Biological target: | Epigenetic Regulation; Class I/II HDACs; HDAC (pan) |
| In vitro activity: | Ki = 3.4 nM; IC₅₀: HDAC1 4.99 nM, HDAC3 5.21 nM, HDAC6 16.4 nM, HDAC10 24.3 nM. Inhibits breast cancer cell lines (mean IC₅₀ 124 nM). |
| In vivo activity: | Antitumor in rat mammary cancer model; inhibits angiogenesis via VEGF suppression in vivo. |
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