12‑Ethyl sirolimus (12‑Ethyl Rapamycin, 12‑Demethyl‑12‑ethylrapamycin, Homorapamycin A) acts through inhibition of mTOR, similar to its parent compound, with expected IC₅₀ values in the low nanomolar range. It contains 15 chiral carbons and 4 substituted double bonds, with configuration corresponding to rapamycin. This compound is a synthetic analogue used in structure‑activity relationship (SAR) studies of mTOR inhibitors and in research exploring the effects of structural modifications on mTOR inhibition and immunosuppressive activity.
Everolimus
Price range: $298.00 through $498.00
Sirolimus isomer C
Price range: $980.00 through $3,980.00
12-Ethyl sirolimus
$2,998.00
CAS Number: 1290606-20-0
Synonyms: 12-Ethyl Rapamycin, 12-Demethyl-12-ethylrapamycin, Homorapamycin A
Mechanism of Action: mTORC1 Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 5mg | $2,998.00 | In stock |
Description
Additional information
| Size |
5mg |
|---|---|
| Purity |
95% |
| M.F. |
C₅₂H₈₁NO₁₃ |
| M.W. |
928.2 |
| Appearance |
Solid |
| Storage |
Store long-term at -20°C |
Biological activity
| Biological target: | #REF! |
| In vitro activity: | |
| In vivo activity: |
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