MMAE (Monomethyl auristatin E, Vedotin) is a potent antimitotic agent that blocks tubulin polymerization with IC₅₀ values less than 1 nM for many cancer cell lines; 5 nM inhibits HCT‑116 cells by 50%. MMAE is a synthetic auristatin derivative. It is the payload in FDA‑approved ADCs brentuximab vedotin (Adcetris®) and enfortumab vedotin (Padcev®). In research, MMAE is used extensively to study ADC efficacy, drug‑linker design, and tumor‑targeted delivery.
MMAE
$998.00
CAS Number: 474645-27-7
Synonyms: Monomethyl auristatin E, Vedotin
Mechanism of Action: β-Tubulin Inhibitor (Vinblastine site)
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 1g | $998.00 | In stock |
Description
Additional information
| Size |
1g |
|---|---|
| Purity |
98% |
| M.F. |
C₃₉H₆₇N₅O₇ |
| M.W. |
717.98 |
| Appearance |
Solid |
| Melting Point |
>90°C (dec.) |
| Storage |
Store long-term at -20°C- |
| Smiles |
CCC@H[C@@H](C@@H- |
| MDL No |
MFCD22124498-锛坅lso MFCD28400134-锛?/span> |
| Harmonized Tariff Codes |
2934.99.9001- |
Biological activity
| Biological target: | Mitosis Regulation; Tubulin; β-Tubulin (Vinblastine site) |
| In vitro activity: | Potent antimitotic; IC₅₀ <1 nM for many cancer cell lines; 5 nM inhibits HCT‑116 by 50%. |
| In vivo activity: | Bombesin‑MMAE improves tumor accumulation in PC‑3 xenografts; cBR96‑Val‑Cit‑MMAE shows activity in L2987 lung adenocarcinoma mouse model. |
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