Epothilone B (EPO 906, Patupilone, NSC 708546) is a potent microtubule‑stabilizing agent that promotes tubulin polymerization and arrests cells in G2‑M phase with an EC₅₀ of 32 nM in HeLa cells. It is active against multidrug‑resistant cells overexpressing P‑glycoprotein. Epothilone B is a 16‑membered macrolide isolated from the myxobacterium Sorangium cellulosum. In research and clinical trials, it has been investigated as an antineoplastic agent, and is used as a model for studying microtubule stabilization and overcoming taxane resistance.
Epothilone B
$899.00
CAS Number: 152044-54-7
Synonyms: EPO 906, Patupilone, NSC 708546
Mechanism of Action: β-Tubulin Stabilizer (Taxol site)
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 75mg | $899.00 | In stock |
Description
Additional information
| Size |
75mg |
|---|---|
| Purity |
98% |
| M.F. |
C₂₇H₄₁NO₆S |
| M.W. |
507.68 |
| Appearance |
White to almost white powder to crystal |
| Melting Point |
95-97°C |
| Storage |
Store long-term at -20°C |
Biological activity
| Biological target: | Mitosis Regulation; Tubulin (microtubule stabilization); β-Tubulin (Taxol/Paclitaxel site) |
| In vitro activity: | Promotes tubulin polymerization; EC₅₀ for G2‑M arrest = 32 nM in HeLa; active against MDR cells. |
| In vivo activity: | Antitumor activity in vivo; induces tubulin hyper‑polymerization in rat sciatic nerve; dose‑dependent neurotoxicity at 0.25‑1.5 mg/kg IV weekly. |
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