Anisomycin (NSC 23219) is a potent inhibitor of peptidyl transferase on the 80S ribosome, suppressing protein synthesis. It also shows activity against dengue and Zika viruses. Anisomycin is a pyrrolidine antibiotic isolated from Streptomyces griseolus. In research, it is used to inhibit translation, study memory consolidation and reconsolidation, and as a JNK activator in signaling studies.
Anisomycin
$599.00
CAS Number: 22862-76-6
Synonyms: NSC 23219, Flagecidin
Mechanism of Action: 60S Ribosome Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 1g | $599.00 | In stock |
Description
Additional information
| Size |
1g |
|---|---|
| Purity |
95% |
| M.F. |
C₁₄H₁₉NO₄ |
| M.W. |
265.31 |
| Appearance |
White crystalline powder |
| Melting Point |
140-141°C |
| Storage |
Store long-term at -20°C |
| Smiles |
CC(=O)O[C@@H]1C@HO- |
Biological activity
| Biological target: | Translation/Protein Synthesis; 80S ribosome (peptidyl transferase); 60S Ribosomal Subunit (peptidyl transferase) |
| In vitro activity: | Inhibits peptidyl transferase; suppresses protein synthesis; active against dengue and Zika viruses. |
| In vivo activity: | Induces macrophage apoptosis in atherosclerotic plaques; decreases prostate cancer metastases in mouse model. |
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