Negamycin (NSC 142075) is a bacterial protein synthesis inhibitor that inhibits translation termination and enhances miscoding. It has an IC₅₀ of 2.8 μM in E. coli cell‑free systems and is efficacious in mouse infection models. Negamycin is a dipeptide antibiotic isolated from Streptomyces purpeofuscus. In research, it is used to study bacterial translation, and as a lead for read‑through of nonsense mutations (e.g., in Duchenne muscular dystrophy).
Negamycin
$19,800.00
CAS Number: 33404-78-3
Synonyms: NSC 142075
Mechanism of Action: Elongation Factor Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 10mg | $19,800.00 | In stock |
Description
Additional information
| Size |
10mg |
|---|---|
| Purity |
95% |
| M.F. |
C₉H₂₀N₄O₄ |
| M.W. |
248.28 |
| Appearance |
Powder |
| Melting Point |
110-120°C (dec.) |
| Storage |
Store long-term at -20°C |
| Smiles |
O=C(O)CN(C)NC(CC@HCC@@HCN)=O- |
Biological activity
| Biological target: | Translation/Protein Synthesis; Bacterial ribosome; Elongation Factor (unknown) |
| In vitro activity: | Inhibits bacterial protein synthesis; IC₅₀ = 2.8 μM in E. coli cell‑free system; restores dystrophin in mdx mouse cells. |
| In vivo activity: | Efficacious in E. coli infection models; restores dystrophin in skeletal and cardiac muscles of mdx mouse. |
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