Romidepsin (FK228, FR901228, NSC 630176) is a potent and selective class I histone deacetylase (HDAC) inhibitor with IC₅₀ values of 1.6 nM for HDAC1, 3.9 nM for HDAC2, and weaker activity against HDAC4 (25 nM) and HDAC6 (79 nM). It is the most potent HDAC inhibitor against Ewing sarcoma cell lines. Romidepsin is a bicyclic depsipeptide (cyclic peptide) isolated from Chromobacterium violaceum (and also from Burkholderia). In research and clinic, it is FDA‑approved for cutaneous and peripheral T‑cell lymphoma (Istodax®) and is widely studied as an epigenetic modulator in cancer and immunotherapy.
Romidepsin
$1,998.00
CAS Number: 128517-07-7
Synonyms: FK228, FR901228, NSC 630176, Istodax
Mechanism of Action: Pan-HDAC Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 100mg | $1,998.00 | In stock |
Description
Additional information
| Size |
100mg |
|---|---|
| Purity |
95% |
| M.F. |
C₂₄H₃₆N₄O₆S₂ |
| M.W. |
540.7 |
| Appearance |
Waxy solid / White powder |
| Melting Point |
219-224°C |
| Storage |
-20°C; powder stable for 2-3 years- |
| Smiles |
C\C=C\1/NC(=O)[C@H]2CSSCC\C=C[C@H](CC(=O)NC@HC(=O)N2)OC(=O)C@@HC(C)C |
| MDL No |
MFCD03848392- |
Biological activity
| Biological target: | Epigenetic Regulation; HDAC1, HDAC2 (class I); HDAC (pan) |
| In vitro activity: | IC₅₀: HDAC1 1.6 nM, HDAC2 3.9 nM, HDAC4 25 nM, HDAC6 79 nM. Most potent HDACi against Ewing sarcoma. |
| In vivo activity: | FDA‑approved for CTCL and PTCL; sensitizes HCC to RTK inhibitors; inhibits tumor growth in DMG xenografts. |
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