Staurosporine (STS, Antibiotic AM‑2282) is a potent, broad‑spectrum protein kinase inhibitor that inhibits PKC (IC₅₀ = 3 nM), p60v‑src (6 nM), PKA (7 nM), CaM kinase II (20 nM), and many other kinases. It induces apoptosis in oral and pancreatic cancer cells with IC₅₀ values in the sub‑micromolar range. Staurosporine is an indolocarbazole alkaloid. It was first isolated from Streptomyces staurosporeus and later found in other actinomycetes. In research, it is widely used as a positive control for apoptosis induction, a kinase inhibitor tool for signaling studies, and a potent inducer of autophagy and neurite outgrowth in neuronal cultures.
Staurosporine
Price range: $398.00 through $998.00
CAS Number: 62996-74-1
Synonyms: STS, Antibiotic AM-2282
Mechanism of Action: Broad-Spectrum PKC/PKA Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 100mg | $398.00 | In stock | |
| 95% | 1g | $998.00 | In stock |
Description
Additional information
| Size |
100mg, 1g |
|---|---|
| Purity |
98%, 95% |
| M.F. |
C₂₈H₂₆N₄O₃ |
| M.W. |
466.53 |
| Appearance |
Yellow crystalline powder |
| Melting Point |
270°C |
| Storage |
Refrigerated (0-10°C); Store under inert gas-21 |
| Smiles |
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC-49 |
| MDL No |
MFCD18252446-21聽(also MFCD00077402-) |
| Precautionary Statement Code |
P273, P501-21 |
| GHS Information |
H413: May cause long lasting harmful effects to aquatic life-21 |
| Harmonized Tariff Codes |
2941.90.0000-21 |
Biological activity
| Biological target: | #REF! |
| In vitro activity: | IC₅₀: PKC 3 nM, p60v‑src 6 nM, PKA 7 nM, CaM KII 20 nM. Induces apoptosis in oral and pancreatic cancer cells; triggers mitophagy. |
| In vivo activity: | Reduces gastric cancer progression in transgenic mouse models; enhances lentiviral transduction of HSCs in vivo. |
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