Ansamitocin P‑3 (Maytansinol isobutyrate, NSC 292445) is a potent microtubule‑targeting agent that binds to β‑tubulin with a Kd of 1.3 μM and inhibits tubulin polymerization with an IC₅₀ of 3.4 μM. It shows antiproliferative activity with IC₅₀ values: MCF‑7 20 pM, HeLa 50 pM, MDA‑MB‑231 150 pM. Ansamitocin P‑3 is a maytansinoid ansamycin antibiotic isolated from Actinosynnema pretiosum. In research, it is used as a potent cytotoxic payload in antibody‑drug conjugates (ADCs) and as a tool to study microtubule dynamics and mitotic arrest.
Ansamitocin P-3
$298.00
CAS Number: 66584-72-3
Synonyms: Maytansinol isobutyrate, Ansamitomicin P-3, AP-3
Mechanism of Action: β-Tubulin Inhibitor (Maytansine site)
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 100mg | $298.00 | In stock |
Description
Additional information
| Size |
100mg |
|---|---|
| Purity |
95% |
| M.F. |
C₃₂H₄₃ClN₂O₉ |
| M.W. |
635.15 |
| Appearance |
White to off-white powder |
| Melting Point |
190-192°C |
| Storage |
Store long-term at 2-8°C- |
| Smiles |
[H][C@@]12O[C@@]1(C)C@HOC(=O)C(C)C |
| MDL No |
MFCD00274586- |
Biological activity
| Biological target: | Mitosis Regulation; Tubulin (β‑tubulin); β-Tubulin (Vinblastine/Maytansine site) |
| In vitro activity: | Inhibits tubulin polymerization with IC₅₀ = 3.4 μM; binds tubulin Kd = 1.3 μM. Antiproliferative IC₅₀: MCF‑7 20 pM, HeLa 50 pM, MDA‑MB‑231 150 pM. |
| In vivo activity: | Used as ADC payload; inhibits microtubule dynamics in vivo. |
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