Epothilone A (EPO 908, NSC 707267) is a naturally occurring microtubule‑stabilizer that promotes tubulin polymerization and induces G2‑M arrest at low nanomolar concentrations. It is structurally similar to epothilone B but lacks a methyl group at C‑12. Epothilone A is isolated from Sorangium cellulosum. In research, it is used as a reference compound for microtubule studies and as a lead for semisynthetic analogs with improved pharmacology.
Epothilone A
$599.00
CAS Number: 152044-53-6
Synonyms: EPO 908, NSC 707267
Mechanism of Action: β-Tubulin Stabilizer (Taxol site)
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 75mg | $599.00 | In stock |
Description
Additional information
| Size |
75mg |
|---|---|
| Purity |
98% |
| M.F. |
C₂₆H₃₉NO₆S |
| M.W. |
493.66 |
| Appearance |
White to off-white powder |
| Melting Point |
95°C |
| Storage |
Store long-term at -20°C |
| Smiles |
C/C(C@HOC(CC@HC(C(C@@HC)=O)(C)C)=O)=C\C3=CSC(C)=N3- |
Biological activity
| Biological target: | Mitosis Regulation; Tubulin; β-Tubulin (Taxol/Paclitaxel site) |
| In vitro activity: | Stabilizes microtubules; induces G2‑M arrest at low nM concentrations. |
| In vivo activity: | Exhibits in vivo antitumor activity similar to Epothilone B. |
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