Didemnin B (NSC 325319) is a cyclic depsipeptide that binds to eEF1A‑GTP‑aa‑tRNA and inhibits translation elongation, showing antiproliferative activity against colorectal, lymphatic, and prostate cancer cells at nanomolar concentrations. It is active against Ehrlich’s carcinoma in mice. Didemnin B is isolated from the marine tunicate Trididemnum solidum. In research, it is used to study protein synthesis inhibition and as a lead for anticancer drug development.
Didemnin B
$898.00
CAS Number: 77327-05-0
Synonyms: NSC 325319
Mechanism of Action: EF-1α Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 98% | 1mg | $898.00 | In stock |
Description
Additional information
| Size |
1mg |
|---|---|
| Purity |
98% |
| M.F. |
C₅₇H₈₇N₇O₁₅ |
| M.W. |
1110.34 |
| Appearance |
White to off-white crystalline solid |
| Storage |
Store long-term at -20°C |
Biological activity
| Biological target: | Translation/Protein Synthesis; eEF1A; EF-1α |
| In vitro activity: | Binds eEF1A‑GTP‑aa‑tRNA; inhibits translation; active against colorectal, lymphatic, prostate cancer at nM concentrations. |
| In vivo activity: | Active against Ehrlich's carcinoma in mice. |
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