Fumagillin (NSC 9168) is an irreversible inhibitor of methionine aminopeptidase 2 (MetAP2) with anti‑angiogenic activity. It inhibits P. falciparum growth and is active against malaria in mouse models. Fumagillin is a sesquiterpene antibiotic isolated from Aspergillus fumigatus. In research, it is used to study angiogenesis and as a lead for MetAP2 inhibitors, and was previously used as an antimicrobial agent.
Fumagillin
$299.00
CAS Number: 23110-15-8
Synonyms: NSC 9168
Mechanism of Action: MetAP-2 Inhibitor
| Purity | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| 95% | 10mg | $299.00 | In stock |
Description
Additional information
| Size |
10mg |
|---|---|
| Purity |
95% |
| M.F. |
C₂₆H₃₄O₇ |
| M.W. |
458.55 |
| Appearance |
White to off-white solid |
| Melting Point |
194-195°C |
| Storage |
Store long-term at -20°C |
| Smiles |
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C- |
Biological activity
| Biological target: | Angiogenesis; MetAP2; MetAP-2 |
| In vitro activity: | Irreversibly inhibits MetAP2; anti‑angiogenic; inhibits P. falciparum growth. |
| In vivo activity: | Active against malaria in mouse model; effective against microsporidia in humans. |
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