Hispidulin is a flavonoid with the classic C6-C3-C6 structural framework, comprising two phenolic rings joined by a three-carbon chain that forms a heterocyclic ring, with the conjugated double bond system enabling efficient free radical scavenging through electron delocalization. Flavonoids of this type are ubiquitously distributed in the plant kingdom, found in fruits, vegetables, seeds, flowers, and bark of numerous plant species, where they function as UV protectants, pigment molecules, and defense compounds against microbial pathogens As a flavonoid, this compound exhibits potent antioxidant activity by scavenging free radicals and chelating metal ions, along with anti-inflammatory, antimicrobial, and anticancer properties that contribute to its well-documented health-promoting effects The compound shows significant bioactivity as an antioxidant, anti-inflammatory agent, and enzyme inhibitor, with additional reported antimicrobial, antiviral, and anticancer activities that make it a promising candidate for nutraceutical and pharmaceutical development This flavonoid exerts its biological effects by modulating multiple signaling pathways including MAPK, PI3K/Akt, and Nrf2, while also interacting with cellular receptors and enzymes involved in oxidative stress and inflammation, with structure-activity studies highlighting the importance of specific hydroxyl positions Current applications include its use as a natural antioxidant in food preservation, as a dietary supplement ingredient for cardiovascular health and immune support, and as a lead compound for developing novel anti-inflammatory and chemopreventive agents with improved bioavailability
Hispidulin
CAS Number: 1447-88-7
Synonym: 4′,5,7-Trihydroxy-6-methoxyflavone; Hispidulin; Dinatin; Salvitin; 6-methoxyapigenin; 6-O-Methylapigenin; 6-methoxy apigenin; 6-O-methylscutellarein
| M.F. |
C16H12O6 |
|---|---|
| M.W. |
300.27 |
| Appearance |
Yellow powder |
| Smiles |
COC1=C(C2=C(C=C1O)OC(=CC2=O)C3=CC=C(C=C3)O)O |
| Storage |
Store at room temperature for short-term use; store at -20°C for long-term storage. |
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